Role of the Proteasome in TGF- Signaling in Lens Epithelial Cells
نویسندگان
چکیده
RESULTS. TGFinduced the expression of -smooth muscle actin, fibronectin, and TGF–inducible gene mRNA in HLE B-3 cells and primary cultured human lens cells from donor tissues. TGFalso induced a time-dependent decrease in the level of the Smad repressor SnoN. -Glutamyl-cysteine synthetase ( GCS) mRNA levels decreased in the presence of TGF. Proteasome inhibitor cotreatment blocked the induction of -SMA mRNA, the loss of SnoN protein, the decrease in -GCS mRNA, and TGF–induced apoptosis.
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تاریخ انتشار 2006